Friday, June 17, 2011

Obesity Surgery Might Not Help Older Patients Live Longer, Study Suggests

June 13, 2011 -- Extremely obese adults who are middle-age or older may not be lengthening their lives by having weight loss surgery, a new study reveals.

These findings differ from previous research, which has shown a modest improvement in survival rates. Other studies done on younger, female, or healthier populations have suggested an increased life span following these procedures.

But this current study looked at an older, predominantly male, and sicker group of adults, and the results did not show a decrease in mortality rates in patients after gastric bypass surgery during a nearly seven-year follow-up period.

"We looked at Roux-en-Y gastric bypass because that was the predominant procedure done when the research was conducted," says study researcher Matthew Maciejewski, PhD, an investigator at the center for Health Services Research in Primary Care at the Durham Veterans Affairs Medical Center in Durham, N.C.

The research appears in the June 15 issue of the Journal of the American Medical Association.

Weight Loss Surgery and Risk of Death

Researchers analyzed data from 850 veterans who had weight loss surgery between January 2000 and December 2006 at one of 12 VA medical centers and a similar number of severely obese high-risk veterans who did not have the operation but received their health care from the same facilities. Among the surgical patients, 74% were male and 26% were female. Their average age was 49 and the average body mass index (BMI) was 47, which is considered severely obese.

When researchers compared mortality rates in the surgical group to a matched nonsurgical control group -- who had a similar age, BMI, race, gender mix, marital status, and number of participants who were super-obese (BMI of 50 or above) -- they did not find a lower mortality rate.

Why didn't gastric bypass extend life? Maciejewski says one possibility is that there is no survival benefit from weight loss surgery in this higher-risk, predominantly male group of patients after nearly seven years. A second explanation is that there could be a longer-term benefit that researchers didn't have enough time to observe.

A study from Sweden with a longer follow-up period found a survival benefit in patients, but it was not seen until an average of 13 years after weight loss surgery.

"In the Swedish research, some of the decreases in mortality found a decade or more later were caused by a reduction in deaths from cancer and heart disease," says Janey Pratt, MD, a bariatric surgeon and director of the Massachusetts General Hospital Weight Loss Center in Boston, who was not involved in either of the two studies. "Perhaps in this latest research, the damage had already been done in older patients, and they're less likely to reap the benefits of surgery in terms of survival.”

Eleven of the 850 surgical patients died within a month of having gastric bypass. That's a mortality rate of 1.3%, which is four times higher than the one seen in an earlier study of weight loss surgery in younger, mostly female patients.

Pratt tells WebMD that it's much more difficult to do obesity surgery on male patients than females because of gender differences in the way fat is distributed on the body.

Women carry more of their fat in their hips and thighs, and belly fat is found mainly in the abdominal wall. But extremely obese men carry much of their fat in the belly, the so-called "apple" shape. They have thin abdominal walls but lots of fat floating around inside surrounding the gastrointestinal tract and organs where weight loss surgery takes place.

Weighing Risks and Benefits of Obesity Surgery

Roughly 220,000 Americans have obesity surgery per year, or 1% of the clinically eligible population, according to the American Society for Metabolic and Bariatric Surgery. These operations, which include gastric bypass or gastric banding, make the stomach smaller so the amount of food eaten is reduced. With gastric bypass, fewer calories are also absorbed because food bypasses part of the small intestine.

"Even though this study did not suggest a survival benefit at nearly seven years, there are a host of other benefits from having bariatric surgery," Maciejewski tells WebMD. It's effective in producing weight loss, it decreases the use of medication for obesity-related health conditions, such as diabetes, high blood pressure, and high cholesterol, and it improves the quality of life.

Pratt frequently does weight loss surgery in people over 60, but she tells her patients that it's unlikely to prolong their life and more likely to improve their quality of life and decrease the number of medications they're currently taking.

Many go ahead and have the procedure. "But sometimes it's the quality of life benefits -- being able to sleep in the same bed as their spouse, sitting comfortably in a movie theater, or cutting their own toenails -- that's enough. It doesn't have to be living longer," says Pratt.

Original source: http://www.webmd.com/diet/weight-loss-surgery/news/20110613/weight-loss-surgery-middle-age-may-not-increase-survival

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Tuesday, June 7, 2011

Bariatric Surgery Linked to Increased Fracture Risk

For those wanting to lose weight, here is yet another reason why NOT to have bariatric surgery, but to participate in a Gastric Band Hypnosis Program such as that provided at the Sanders Hypnosis Center in Glen Burnie, Maryland instead.

New research has found that people who have had gastric bypass surgery or other bariatric weight-loss surgery have an even higher increased risk of breaking bones than previously found. These study findings will be presented Tuesday at The Endocrine Society’s 93rd Annual Meeting in Boston.

“A negative effect on bone health that may increase the risk of fractures is an important consideration for people considering bariatric surgery and those who have undergone bariatric surgery,” said lead author Kelly Nakamura, a medical student at Mayo Clinic College of Medicine in Rochester, Minn.

Nakamura reported the final analysis of research presented two years ago in a small subset of the 258 patients included in this study. This full analysis showed that patients who had bariatric surgery have 2.3 times the chance of fractures compared with the general population, as opposed to the 1.8-fold increased risk found initially.

Patients who had bariatric surgery had an increased risk of a fracture at nearly all skeletal sites studied, according to the authors. The chance of breaking a foot or hand was especially high—about three times what would be expected, Nakamura said.

For comparison, the investigators studied the patients’ actual fracture rates reported in their medical records versus the expected fracture rates among people of the same age and sex living in the same county in Minnesota. Patients underwent bariatric surgery at Mayo Clinic Rochester between 1985 and 2004, with 94 percent of patients having a gastric bypass.

A total of 79 patients had 132 fractures during an average follow-up of nine years, the authors reported. On average, they experienced their first fracture about six years after surgery. This is a time when their primary health care provider, rather than their surgeon, usually is responsible for their care, said the study’s principal investigator, Kurt Kennel, MD, an assistant professor of medicine in the endocrinology division at Mayo Clinic.

After evaluating various fracture risk factors, the researchers found that patients who were more physically active before surgery had a lower fracture risk than those who were less active. Some of these obese patients may have been too debilitated to exercise, Kennel suggested.

“Clinicians may need to consider measures to optimize bone health and reduce fracture risk after bariatric surgery, such as fall prevention and optimizing calcium and vitamin D nutrition,” he said.

Kennel stressed, however, that the patients who had fractures did not necessarily develop osteoporosis. He said, “There are no data on whether bisphosphonates [osteoporosis medications] are safe or appropriate for this patient population. Further research is needed to understand why bariatric surgery negatively affects bone health and how best to prevent these fractures.”

Released: 6/3/2011 11:00 AM EDT
Embargo expired: 6/4/2011 2:00 PM EDT
Source: Endocrine Society

Aaron Lohr
alohr@endo-society.org
240-482-1380
www.newswise.com/articles/view/577410?print-article

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